The retrovirus genome comprises two identical, plus-sense ssRNA molecules, each monomer 7—11 kb in size, that are noncovalently linked over a short terminal region. Retroviruses contain 2 envelope proteins encoded by the env-gene, 4—6 nonglycosylated core proteins and 3 non-structural functional proteins reverse transcriptase, integrase, protease: RT, IN, PR specified by the gag-gene Fig.
This DNA, mediated by the viral integrase, becomes covalently bonded into the DNA of the host cell to make possible the subsequent transcription of the sense strands that eventually give rise to retrovirus progeny. After assembly and budding, retroviruses show structural and functional maturation. In immature virions the structural proteins of the core are present as a large precursor protein shell. After proteolytic processing by the viral protease the proteins of the mature virion are rearranged and form the dense isometric or cone-shaped core typical of the mature virion, and the particle becomes infectious.
Most DNA viruses Fig. The papovaviruses, comprising the polyoma- and papillomaviruses, however, have circular DNA genomes, about 5. Three or 2 structural proteins make up the papovavirus capsid: in addition, nonstructural proteins are encoded that are functional in virus transcription, DNA replication and cell transformation. Single-stranded linear DNA, 4—6 kb in size, is found with the members of the Parvovirus family that comprises the parvo-, the erythro- and the dependoviruses.
The virion contains 2—4 structural protein species which are differently derived from the same gene product see Ch. The adeno-associated virus AAV, a dependovirus is incapable of producing progeny virions except in the presence of helper viruses adenovirus or herpesvirus. It is therefore said to be replication defective. Circular single-stranded DNA of only 1.
The isometric capsid measures 17 nm and is composed of 2 protein species only. On the basis of shared properties viruses are grouped at different hierarchical levels of order, family, subfamily, genus and species.
More than 30, different virus isolates are known today and grouped in more than 3, species, in genera and 71 families. Viral morphology provides the basis for grouping viruses into families. A virus family may consist of members that replicate only in vertebrates, only in invertebrates, only in plants, or only in bacteria.
Certain families contain viruses that replicate in more than one of these hosts. This section concerns only the 21 families and genera of medical importance. Besides physical properties, several factors pertaining to the mode of replication play a role in classification: the configuration of the nucleic acid ss or ds, linear or circular , whether the genome consists of one molecule of nucleic acid or is segmented, and whether the strand of ss RNA is sense or antisense. Also considered in classification is the site of viral capsid assembly and, in enveloped viruses, the site of nucleocapsid envelopment.
Table lists the major chemical and morphologic properties of the families of viruses that cause disease in humans. The use of Latinized names ending in -viridae for virus families and ending in -virus for viral genera has gained wide acceptance.
The names of subfamilies end in -virinae. Vernacular names continue to be used to describe the viruses within a genus. In this text, Latinized endings for families and subfamilies usually are not used. Table shows the current classification of medically significant viruses. In the early days of virology, viruses were named according to common pathogenic properties, e.
From the early s until the mids, when many new viruses were being discovered, it was popular to compose virus names by using sigla abbreviations derived from a few or initial letters.
Thus the name Picornaviridae is derived from pico small and RNA; the name Reoviridae is derived from respiratory, enteric, and orphan viruses because the agents were found in both respiratory and enteric specimens and were not related to other classified viruses; Papovaviridae is from papilloma, polyoma, and vacuolating agent simian virus 40 [SV40] ; retrovirus is from reverse transcriptase; Hepadnaviridae is from the replication of the virus in hepatocytes and their DNA genomes, as seen in hepatitis B virus.
Hepatitis A virus is classified now in the family Picornaviridae, genus Hepatovirus. Although the current rules for nomenclature do not prohibit the introduction of new sigla, they require that the siglum be meaningful to workers in the field and be recognized by international study groups. Several viruses of medical importance still remain unclassified. Some are difficult or impossible to propagate in standard laboratory host systems and thus cannot be obtained in sufficient quantity to permit more precise characterization.
Hepatitis E virus, the Norwalk virus and similar agents see Ch. The fatal transmissible dementias in humans and other animals scrapie in sheep and goat; bovine spongiform encephalopathy in cattle, transmissible mink encephalopathy; Kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler-Scheinker syndrome in humans see Ch.
The agents causing transmissible subacute spongiform encephalopathies have been linked to viroids or virinos i. Some of the transmissible amyloidoses show a familial pattern and can be explained by defined mutations which render a primary soluble glycoprotein insoluble, which in turn leads to the pathognomonic accumulation of amyloid fibers and plaques. The pathogenesis of the sporadic amyloidoses, however, is still a matter of highly ambitious research.
Turn recording back on. National Center for Biotechnology Information , U. Show details Baron S, editor. Search term. Theor Popul Biol 61, — Boyer, M. Phylogenetic and phyletic studies of informational genes in genomes highlight existence of a 4 th domain of life including giant viruses.
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Parasitol Res , — Image: Coloured transmission electron micrograph of a group of foot-and-mouth disease viruses. Human adenovirus type 5 and sulfolobus turreted icosahedral virus 2.
David Bhella. Are viruses alive? Issue: What is life? Back to issue. Ask the Editors 'Everyday' vs. What Is 'Semantic Bleaching'? How 'literally' can mean "figuratively". Literally How to use a word that literally drives some pe Is Singular 'They' a Better Choice? The awkward case of 'his or her'. New Year, Recondite Vocabulary Take the quiz. Advanced Vocabulary Quiz Tough words and tougher competition. Take the quiz.
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